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Although regimens for treatment of glioblastoma multiforme (GBM) with recurrent disease are limited, combination chemotherapy is typically recommended after resection of the primary tumor. In a patient with a left inferior temporal lobe GBM, progression on standard therapy, 1st line palliative chemotherapy (carboplatin/etoposide) was followed by a further progression and recurrence at the primary site. To this end, the patient was enrolled on a phase II trial of oral mTOR inhibitor, everolimus. He had a dramatic response to treatment, extending his survival beyond 6 months. The patient had a survival advantage of nearly 7 months from recurrence and developed a meaningful quality of life. Recent advances in the treatment of brain tumors demonstrate a benefit in survival when patients are enrolled on clinical trials. In patients with recurrent GBM that are eligible for trials, the option of enrollment on an on-going trial should be considered.Thoughts, musings, and observations about life, the universe, and anything else that strikes my fancy.
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Gas springs are used in a wide variety of applications, including vehicle seating, such as those found in passenger vehicles, as well as the actuation of a wide variety of mechanical devices. As will be appreciated, it is often desirable to have the capability to adjust the length of a gas spring device in order to compensate for manufacturing tolerances and/or use-related degradation of the gas spring device. The ability to adjust the length of a gas spring device, and/or vary the rate of inflation of the gas spring device, allows the gas spring device to function in an optimal manner under a variety of conditions.
Traditionally, gas springs have been configured as either a single-stage spring or a multiple-stage spring. A single-stage spring is configured to provide a generally constant rate of inflation throughout the full travel of the spring, whereas a multiple-stage spring has a gas spring device that is divided into a number of discrete stages, each of which provides a relatively small change in the length of the gas spring device. As will be appreciated, an effective gas spring device can be difficult to control and maintain due to the wide range of operating conditions under which the gas spring device is typically used, including the large amount of stress and wear that can be placed on the gas spring device. For example, the ability to control and maintain a gas spring device
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AutoCAD is a registered trademark of Autodesk, Inc. Autocad, AutoCAD, ACAD, and acad.net are registered trademarks of Autodesk, Inc. Other brand and product names are trademarks or registered trademarks of their respective holders.Stephen Trott
Stephen Trott (died 4 October 1742) was a British army officer who was involved in the Jacobite rising of 1745.
Trott was a British Army officer who had served in the Jacobite rising of 1715. The failure of that rising resulted in Trott’s dismissal from the army.
He then served as a commissioned officer in the Jacobite army. Trott supported the pretender, the ‘Young Pretender’ James Francis Edward Stuart, and was made a British general in the Jacobite army. He commanded the Scottish Jacobite forces under the pretender at the Battle of Sheriffmuir in 1715, the Battle of Preston Moor in 1715 and the Battle of the Falkirk in 1746.
By the 1740s Trott was back in the British Army, serving in the British Army, this time as a lieutenant colonel. By the time of the Jacobite rising of 1745 he was a colonel and was an officer in the 12th Regiment of Foot. He was promoted to brigadier-general and sent to Scotland with troops to support the Stuart cause. Trott was opposed to the rising because of his experience in 1715 and refused to take part in it.
In 1745 Trott was at Leith at the time of the battle of Culloden, where the Jacobite army, commanded by the ‘Young Pretender’, was defeated. After the battle Trott was not at Culloden, but he was later held responsible for the actions of the deserters who slipped out of the army at the battle. Trott was to spend the rest of his life in prison in England.
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