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If you successfully sent a and if you are in the right website you may click on the following link to open a manual:Coffee consumption and cognitive decline in the elderly: the Busselton Health Study. This study investigated whether habitual coffee consumption in the elderly is associated with cognitive decline. In total, 1,101 community-dwelling subjects aged 65 years or older (mean age 74 years) were followed over a 6-year period. Changes in performance on the Mini-Mental State Examination (MMSE) and the Rowland Universal Dementia Assessment Scale (RUDAS), the outcomes of interest, were examined using a mixed-effects regression model adjusted for gender, education, age at baseline, and study location. At each annual follow-up, subjects were categorized according to the number of cups of coffee they consumed daily: non- or light (1-2 cups/d), moderate (3-4 cups/d), or high (5 cups/d or more). Both high (relative rate (RR) = 1.26; 95% confidence interval (CI): 1.04-1.54) and moderate coffee consumption (RR = 1.32; 95% CI: 1.08-1.62) were associated with an increased risk of decline in global cognitive function (MMSE) but not for neuropsychological (RUDAS) measures. A dose-response relationship was observed for total coffee intake; that is, subjects in the highest category had a 32% increased risk of a global cognitive function decline compared with those in the lowest category (RR = 1.32; 95% CI: 1.06-1.63). The findings of the present study suggest that moderate coffee consumption may adversely affect global cognitive function in the elderly, but this finding needs to be investigated in longitudinal studies with larger sample sizes.4.5+% Club About 4.5+% Club is a money saving savings account that pays you a guaranteed monthly interest rate, depending on how much you have saved and how old you are. 4.5+% Club accounts have been designed to help people to accumulate wealth – in fact, they can even help people save more of their salary than they might have otherwise. Each month, you’ll get paid back 4.5% of the amount that you deposit in your 4.5+% Club account. This is guaranteed no matter what happens to the Bank of England’s money growth



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